PYRIMIDINE METABOLISM REGULATOR-MEDIATED MOLECULAR SUBTYPES DISPLAY TUMOR MICROENVIRONMENTAL HALLMARKS AND ASSIST PRECISION TREATMENT IN BLADDER CANCER

BackgroundBladder cancer (BLCA) is a common urinary system malignancy with a significant morbidity and death rate worldwide.Non-muscle invasive BLCA accounts for over 75% of all BLCA cases.The imbalance of tumor metabolic pathways is associated with tumor formation and proliferation.Pyrimidine metabolism (PyM) is a complex enzyme network that incor

Objective: To evaluate the clinical and radiological outcome of MTA in nonvital teeth with open apices.Methods: Twenty-five non-vital teeth with open apices were treated with MTA apexification procedure.Standard endodontic procedures were followed and an apical plug of at least 5 mm was created by using MTA after a calcium hydroxide intra-canal dre

For practical utilization of proton-conducting ceramic fuel cells and electrolyzers, it is essential to lower the sintering temperature and processing time of BaZrO3-based proton conductors.We investigated the effect of sintering temperature and time on the structural and electrochemical properties of dense BaZr0.8Y0.2O3−δ (BZY) prepared

This research aims to survey the field of batik-related studies within the Scopus database.The chosen methodology involves bibliometric analysis, utilizing the keyword "Batik" to gather data from Scopus.The collected data is then processed and examined through the Publish or Perish and simply southern cat shirt VOSviewer applications to present vis

Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite.Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and metabolic disorders such as diabetes and hyperlipidemia, contributing to endothelial dysfunction.There